This may be more of a perfect storm situation here, than a major concern across all SSRS Scale out deployments using an F5 hardware load balancer. Ill detail what I found & how we were able to workaround & eventually resolve this issue.
The 3 components that affected & essentially caused this issue are:
- F5 Network Load Balancer
- SQL Server Reporting Services (2014, though I believe all versions would be affected)
- VMWare Windows Server 2012 R2 Virtual machine(s)